Abstract Background asthma, chronic obstructive pulmonary disease (COPD), and idiopathic pulmonary fibrosis (IPF) are three serious pulmonary diseases that contain common and unique characteristics.Therefore, the identification of biomarkers that differentiate these diseases is of importance for preventing misdiagnosis.In this regard, the present s
The development of effective and broad-spectrum antiviral therapies remains an unmet need.Current virus-targeted antiviral strategies are often limited by narrow spectrum of activity and the rapid emergence of resistance.As a result, there is increasing interest in alternative approaches that target host cell factors critical for viral replication.
Abstract CRISPR-associated (Cas) transposases (CAST) are RNA-guided systems capable loader of programmable integration of large segments of DNA without creating double-strand breaks.Engineered Cascade CAST function in human cells but are challenging to deploy due to the complexity of the targeting components.Unlike Cascade, which require three Cas
There are many ways to assess face perception skills.In this study, we describe a novel task battery FEAST (Facial Expression Action Stimulus Test) developed to test recognition of identity and expressions of Human Hair Piece human faces as well as stimulus control categories.The FEAST consists of a neutral and emotional face memory task, a face an
The ubiquitin system has emerged as a master regulator of many, if not all, cellular functions.With its large repertoire of conjugating and ligating enzymes, the ubiquitin system holds a unique mechanism to provide selectivity and MAKEUP specificity in manipulating protein function.As intracellular parasites viruses have evolved to modulate the cel